COX-2/mPGES-1/PGE(2) cascade activation mediates uric acid-induced mesangial cell proliferation

Hyperuricemia is not only the main feature of gout but also a cause of gout-related organ injuries including glomerular hypertrophy and sclerosis. Uric acid (UA) has been proven to directly cause mesangial cell (MC) proliferation with elusive mechanisms. The present study was undertaken to examined...

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Pubblicato in:Oncotarget
Autori principali: Li, Shuzhen, Sun, Zhenzhen, Zhang, Yue, Ruan, Yuan, Chen, Qiuxia, Gong, Wei, Yu, Jing, Xia, Weiwei, He, John Ci-Jiang, Huang, Songming, Zhang, Aihua, Ding, Guixia, Jia, Zhanjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354651/
https://ncbi.nlm.nih.gov/pubmed/28052039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14363
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