COX-2/mPGES-1/PGE(2) cascade activation mediates uric acid-induced mesangial cell proliferation

Hyperuricemia is not only the main feature of gout but also a cause of gout-related organ injuries including glomerular hypertrophy and sclerosis. Uric acid (UA) has been proven to directly cause mesangial cell (MC) proliferation with elusive mechanisms. The present study was undertaken to examined...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Li, Shuzhen, Sun, Zhenzhen, Zhang, Yue, Ruan, Yuan, Chen, Qiuxia, Gong, Wei, Yu, Jing, Xia, Weiwei, He, John Ci-Jiang, Huang, Songming, Zhang, Aihua, Ding, Guixia, Jia, Zhanjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354651/
https://ncbi.nlm.nih.gov/pubmed/28052039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14363
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