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Heat shock protein 90 and calcineurin pathway inhibitors enhance the efficacy of triazoles against Scedosporium prolificans via induction of apoptosis

Scedosporium prolificans is a pathogenic mold resistant to current antifungals, and infection results in high mortality. Simultaneous targeting of both ergosterol biosynthesis and heat shock protein 90 (Hsp90) or the calcineurin pathway in S. prolificans may be an important strategy for enhancing th...

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Bibliografske podrobnosti
izdano v:Microb Cell
Main Authors: Shirazi, Fazal, Kontoyiannis, Dimitrios P.
Format: Artigo
Jezik:Inglês
Izdano: Shared Science Publishers OG 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354560/
https://ncbi.nlm.nih.gov/pubmed/28357242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2014.06.150
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