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Heat shock protein 90 and calcineurin pathway inhibitors enhance the efficacy of triazoles against Scedosporium prolificans via induction of apoptosis

Scedosporium prolificans is a pathogenic mold resistant to current antifungals, and infection results in high mortality. Simultaneous targeting of both ergosterol biosynthesis and heat shock protein 90 (Hsp90) or the calcineurin pathway in S. prolificans may be an important strategy for enhancing th...

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Bibliografiske detaljer
Udgivet i:Microb Cell
Main Authors: Shirazi, Fazal, Kontoyiannis, Dimitrios P.
Format: Artigo
Sprog:Inglês
Udgivet: Shared Science Publishers OG 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354560/
https://ncbi.nlm.nih.gov/pubmed/28357242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2014.06.150
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