Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism

The human dopamine transporter (DAT) has a tetrahedral Zn(2+)-binding site. Zn(2+)-binding sites are also recognized by other first-row transition metals. Excessive accumulation of manganese or of copper can lead to parkinsonism because of dopamine deficiency. Accordingly, we examined the effect of...

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Vydáno v:J Biol Chem
Hlavní autoři: Li, Yang, Mayer, Felix P., Hasenhuetl, Peter S., Burtscher, Verena, Schicker, Klaus, Sitte, Harald H., Freissmuth, Michael, Sandtner, Walter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354487/
https://ncbi.nlm.nih.gov/pubmed/28096460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.760140
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