Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway

Human parvovirus B19 (B19V) infection of primary human erythroid progenitor cells (EPCs) arrests infected cells at both late S-phase and G2-phase, which contain 4N DNA. B19V infection induces a DNA damage response (DDR) that facilitates viral DNA replication but is dispensable for cell cycle arrest...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Xu, Peng, Zhou, Zhe, Xiong, Min, Zou, Wei, Deng, Xuefeng, Ganaie, Safder S., Kleiboeker, Steve, Peng, Jianxin, Liu, Kaiyu, Wang, Shengqi, Ye, Shui Qing, Qiu, Jianming
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354443/
https://ncbi.nlm.nih.gov/pubmed/28264028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006266
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