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The HDAC inhibitor SB939 overcomes resistance to BCR-ABL kinase Inhibitors conferred by the BIM deletion polymorphism in chronic myeloid leukemia

Chronic myeloid leukemia (CML) treatment has been improved by tyrosine kinase inhibitors (TKIs) such as imatinib mesylate (IM) but various factors can cause TKI resistance in patients with CML. One factor which contributes to TKI resistance is a germline intronic deletion polymorphism in the BCL2-li...

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Publicat a:PLoS One
Autors principals: Rauzan, Muhammad, Chuah, Charles T. H., Ko, Tun Kiat, Ong, S. Tiong
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354438/
https://ncbi.nlm.nih.gov/pubmed/28301600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174107
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