The structure, dynamics and selectivity profile of a Na(V)1.7 potency-optimised huwentoxin-IV variant

Venom-derived peptides have attracted much attention as potential lead molecules for pharmaceutical development. A well-known example is Huwentoxin-IV (HwTx-IV), a peptide toxin isolated from the venom of the Chinese bird-eating spider Haplopelma schmitdi. HwTx-IV was identified as a potent blocker...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina, Mobli, Mehdi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354290/
https://ncbi.nlm.nih.gov/pubmed/28301520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173551
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