Interplay of myosin phosphatase and protein phosphatase-2A in the regulation of endothelial nitric-oxide synthase phosphorylation and nitric oxide production

The inhibitory phosphorylation of endothelial nitric oxide (NO) synthase (eNOS) at Thr497 (eNOS(pThr497)) by protein kinase C or RhoA-activated kinase is a major regulatory determinant of eNOS activity. The signalling mechanisms involved in the dephosphorylation of eNOS(pThr497) have not yet been cl...

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Pubblicato in:Sci Rep
Autori principali: Bátori, Róbert, Bécsi, Bálint, Nagy, Dénes, Kónya, Zoltán, Hegedűs, Csaba, Bordán, Zsuzsanna, Verin, Alexander, Lontay, Beáta, Erdődi, Ferenc
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353758/
https://ncbi.nlm.nih.gov/pubmed/28300193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44698
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