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Components of a mammalian protein disaggregation/refolding machine are targeted to nuclear speckles following thermal stress in differentiated human neuronal cells

Heat shock proteins (Hsps) are a set of highly conserved proteins involved in cellular repair and protective mechanisms. They counter protein misfolding and aggregation that are characteristic features of neurodegenerative diseases. Hsps act co-operatively in disaggregation/refolding machines that a...

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Detalhes bibliográficos
Publicado no:Cell Stress Chaperones
Main Authors: Deane, Catherine A. S., Brown, Ian R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352593/
https://ncbi.nlm.nih.gov/pubmed/27966060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-016-0753-x
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