Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer

In immune cells, CD73 dephosphorylates and converts extracellular AMP into adenosine, which binds the A2A adenosine receptor (A2AR). Blockade of this interaction, which induces an immunosuppressed niche in the tumor microenvironment, represents a potential novel treatment strategy. The clinical sign...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Inoue, Yusuke, Yoshimura, Katsuhiro, Kurabe, Nobuya, Kahyo, Tomoaki, Kawase, Akikazu, Tanahashi, Masayuki, Ogawa, Hiroshi, Inui, Naoki, Funai, Kazuhito, Shinmura, Kazuya, Niwa, Hiroshi, Suda, Takafumi, Sugimura, Haruhiko
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352437/
https://ncbi.nlm.nih.gov/pubmed/28060732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14434
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