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Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer

Epithelial ovarian cancer (EOC) is the leading cause of death for gynecological cancer. Most patients are not diagnosed until the cancer is at an advanced stage with poor prognosis. Notch1 signaling pathway plays an oncogenic role in EOC. There have been few studies on enzymatic activity of γ-secret...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Feng, Zhaoyi, Xu, Wandong, Zhang, Chenguang, Liu, Mengran, Wen, Hongwu
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352395/
https://ncbi.nlm.nih.gov/pubmed/28030808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14152
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