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Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer

Epithelial ovarian cancer (EOC) is the leading cause of death for gynecological cancer. Most patients are not diagnosed until the cancer is at an advanced stage with poor prognosis. Notch1 signaling pathway plays an oncogenic role in EOC. There have been few studies on enzymatic activity of γ-secret...

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Vydáno v:Oncotarget
Hlavní autoři: Feng, Zhaoyi, Xu, Wandong, Zhang, Chenguang, Liu, Mengran, Wen, Hongwu
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352395/
https://ncbi.nlm.nih.gov/pubmed/28030808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14152
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