Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice

During aging, uncontrolled epithelial cell proliferation in the uterus results in endometrial hyperplasia and/or cancer development. The mTOR signaling pathway is one of the major regulators of aging as suppression of this pathway prolongs lifespan in model organisms. Genetic alterations in this pat...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Bajwa, Preety, Nielsen, Sarah, Lombard, Janine M., Rassam, Loui, Nahar, Pravin, Rueda, Bo R., Wilkinson, J. Erby, Miller, Richard A., Tanwar, Pradeep S
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
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Priority Research Paper: Gerotarget
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352319/
https://ncbi.nlm.nih.gov/pubmed/27980219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13919
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