Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium

Ovarian cancer is a disease of older women. However, the molecular mechanisms of ovarian aging and their contribution to the pathogenesis of ovarian cancer are currently unclear. mTOR signalling is a major regulator of aging as suppression of this pathway extends lifespan in model organisms. Overact...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bajwa, Preety, Nagendra, Prathima B., Nielsen, Sarah, Sahoo, Subhransu S., Bielanowicz, Amanda, Lombard, Janine M., Wilkinson, Erby J., Miller, Richard A., Tanwar, Pradeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991377/
https://ncbi.nlm.nih.gov/pubmed/27036037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8468
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