Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells

Proliferation and survival of chronic lymphocytic leukemia (CLL) cells depend on microenvironmental signals coming from lymphoid organs. One of the key players involved in the crosstalk between CLL cells and the microenvironment is the B-cell receptor (BCR). Syk protein, a tyrosine kinase essential...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Purroy, Noelia, Carabia, Júlia, Abrisqueta, Pau, Egia, Leire, Aguiló, Meritxell, Carpio, Cecilia, Palacio, Carles, Crespo, Marta, Bosch, Francesc
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352193/
https://ncbi.nlm.nih.gov/pubmed/27888629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13557
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