Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells

Proliferation and survival of chronic lymphocytic leukemia (CLL) cells depend on microenvironmental signals coming from lymphoid organs. One of the key players involved in the crosstalk between CLL cells and the microenvironment is the B-cell receptor (BCR). Syk protein, a tyrosine kinase essential...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Purroy, Noelia, Carabia, Júlia, Abrisqueta, Pau, Egia, Leire, Aguiló, Meritxell, Carpio, Cecilia, Palacio, Carles, Crespo, Marta, Bosch, Francesc
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352193/
https://ncbi.nlm.nih.gov/pubmed/27888629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13557
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