ZAP-70 Promotes the Infiltration of Malignant B-Lymphocytes into the Bone Marrow by Enhancing Signaling and Migration after CXCR4 Stimulation

ZAP-70 in chronic lymphocytic leukemia (CLL) is associated with enhanced response to microenvironmental stimuli. We analyzed the functional consequences of ZAP-70 ectopic expression in malignant B-cells in a xenograft mouse model of disseminated B-cell leukemia. Mice injected with B-cells expressing...

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Detalhes bibliográficos
Main Authors: Calpe, Eva, Purroy, Noelia, Carpio, Cecilia, Abrisqueta, Pau, Carabia, Júlia, Palacio, Carles, Castellví, Josep, Crespo, Marta, Bosch, Francesc
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849145/
https://ncbi.nlm.nih.gov/pubmed/24312539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081221
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