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Acquired resistance to BRAF inhibition in BRAF(V600E) mutant gliomas
Activating mutation of BRAF is a common finding in pediatric gliomas. As many as 14% of high grade and up to 66% of certain subtypes of low grade pediatric glioma have the BRAF(V600E) mutation. Small molecule inhibitors that selectively target BRAF(V600E) are FDA approved for melanoma and have shown...
में बचाया:
| में प्रकाशित: | Oncotarget |
|---|---|
| मुख्य लेखकों: | , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Impact Journals LLC
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5352180/ https://ncbi.nlm.nih.gov/pubmed/27611946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11882 |
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