Novel multi-targeted ErbB family inhibitor afatinib blocks EGF-induced signaling and induces apoptosis in neuroblastoma

Neuroblastoma is the most common extracranial solid tumor in children. The ErbB family of proteins is a group of receptor tyrosine kinases that promote the progression of various malignant cancers including neuroblastoma. Thus, targeting them with small molecule inhibitors is a promising strategy fo...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Mao, Xinfang, Chen, Zhenghu, Zhao, Yanling, Yu, Yang, Guan, Shan, Woodfield, Sarah E., Vasudevan, Sanjeev A., Tao, Ling, Pang, Jonathan C., Lu, Jiaxiong, Zhang, Huiyuan, Zhang, Fuchun, Yang, Jianhua
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352076/
https://ncbi.nlm.nih.gov/pubmed/27902463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13657
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