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Most brain disease-associated and eQTL haplotypes are not located within transcription factor DNase-seq footprints in brain

Dense genotyping approaches have revealed much about the genetic architecture both of gene expression and disease susceptibility. However, assigning causality to genetic variants associated with a transcriptomic or phenotypic trait presents a far greater challenge. The development of epigenomic reso...

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Détails bibliographiques
Publié dans:Hum Mol Genet
Auteurs principaux: Handel, Adam E., Gallone, Giuseppe, Zameel Cader, M., Ponting, Chris P.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351933/
https://ncbi.nlm.nih.gov/pubmed/27798116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw369
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