Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer

PAX8-PPARG fusion protein (PPFP) results from a t(2;3)(q13;p25) chromosomal translocation, is found in 30% of follicular thyroid carcinomas, and demonstrates oncogenic capacity in transgenic mice. A PPARG ligand, pioglitazone, is highly therapeutic in mice with PPFP thyroid cancer. However, only lim...

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發表在:Oncotarget
Main Authors: Zhang, Yanxiao, Yu, Jingcheng, Grachtchouk, Vladimir, Qin, Tingting, Lumeng, Carey N, Sartor, Maureen A, Koenig, Ronald J
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351587/
https://ncbi.nlm.nih.gov/pubmed/28008156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14050
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