Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activity of Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment

Cenicriviroc, a dual CCR2/CCR5 antagonist, is being evaluated for treatment of nonalcoholic steatohepatitis and liver fibrosis (CENTAUR; NCT02217475). As it is metabolized by the liver, cenicriviroc was investigated in hepatic‐impaired participants for pharmacokinetic changes. Participants with mild...

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Bibliografiske detaljer
Udgivet i:Clin Transl Sci
Main Authors: Lefebvre, E, Gottwald, M, Lasseter, K, Chang, W, Willett, M, Smith, PF, Somasunderam, A, Utay, NS
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351328/
https://ncbi.nlm.nih.gov/pubmed/27169903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12397
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