Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

BACKGROUND & AIMS: Interactions between C-C chemokine receptor types 2 (CCR2) and 5 (CCR5) and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting monocyte/macrophage recruitment and tissue infiltration, as well as hepatic stellate cell activation. Cenicriviroc (CVC) is an...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lefebvre, Eric, Moyle, Graeme, Reshef, Ran, Richman, Lee P., Thompson, Melanie, Hong, Feng, Chou, Hsin-l, Hashiguchi, Taishi, Plato, Craig, Poulin, Dominic, Richards, Toni, Yoneyama, Hiroyuki, Jenkins, Helen, Wolfgang, Grushenka, Friedman, Scott L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922569/
https://ncbi.nlm.nih.gov/pubmed/27347680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158156
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