The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B

Butyrate response factor (BRF1) belongs to the Tis11 family of CCCH zinc-finger proteins, which bind to mRNAs containing an AU-rich element (ARE) in their 3′ untranslated region and promote their deadenylation and rapid degradation. Independent signal transduction pathways have been reported to stab...

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Autors principals: Schmidlin, Martin, Lu, Min, Leuenberger, Sabrina A, Stoecklin, Georg, Mallaun, Michel, Gross, Brigitte, Gherzi, Roberto, Hess, Daniel, Hemmings, Brian A, Moroni, Christoph
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2004
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC535089/
https://ncbi.nlm.nih.gov/pubmed/15538381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600477
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