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Reduced responses to glutamate receptor agonists follow loss of astrocytes and astroglial glutamate markers in the nucleus tractus solitarii

Saporin (SAP) or SAP conjugates injected into the nucleus tractus solitarii (NTS) of rats kill astrocytes. When injected in its unconjugated form, SAP produces no demonstrable loss of or damage to local neurons. However bilateral injections of SAP significantly attenuate responses to activation of b...

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Bibliografiske detaljer
Udgivet i:Physiol Rep
Main Authors: Talman, William T., Dragon, Deidre Nitschke, Lin, Li‐Hsien
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350171/
https://ncbi.nlm.nih.gov/pubmed/28270593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13158
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