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The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing α(v)β(3) integrin in chick embryo and nude mouse models
Echistatin, a cyclic RGD peptide, which is an antagonist of α(v)β(3) integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model. A high-metastatic variant of human osteosarcoma, 143...
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Publicado en: | Oncotarget |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado: |
Impact Journals LLC
2016
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Assuntos: | |
Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5349968/ https://ncbi.nlm.nih.gov/pubmed/27894082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13497 |
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