Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells

[Image: see text] The Sonic Hedgehog (Shh) signaling pathway plays a critical role during embryonic development and cancer progression. N-terminal palmitoylation of Shh by Hedgehog acyltransferase (Hhat) is essential for efficient signaling, raising interest in Hhat as a novel drug target. A recentl...

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Publicado en:ACS Chem Biol
Autores principales: Rodgers, Ursula R., Lanyon-Hogg, Thomas, Masumoto, Naoko, Ritzefeld, Markus, Burke, Rosemary, Blagg, Julian, Magee, Anthony I., Tate, Edward W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2016
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349656/
https://ncbi.nlm.nih.gov/pubmed/27779865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00896
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