Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

Pathogenic meningococci have acquired a 24 kb capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and associated capsule transport genes flanked by repetitive Regions D and D’. Regions D and D’ contain an intact gene encoding a UDP-galactose epimerase (galE...

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Udgivet i:Sci Rep
Main Authors: Bartley, Stephanie N., Mowlaboccus, Shakeel, Mullally, Christopher A., Stubbs, Keith A., Vrielink, Alice, Maiden, Martin C. J., Harrison, Odile B., Perkins, Timothy T., Kahler, Charlene M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349592/
https://ncbi.nlm.nih.gov/pubmed/28290510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44442
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