Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism

Mutations in nuclear genes associated with defective coenzyme A biosynthesis have been identified as responsible for some forms of neurodegeneration with brain iron accumulation (NBIA), namely PKAN and CoPAN. PKAN are defined by mutations in PANK2, encoding the pantothenate kinase 2 enzyme, that acc...

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Detalhes bibliográficos
Publicado no:Microb Cell
Main Authors: Ceccatelli Berti, Camilla, Dallabona, Cristina, Lazzaretti, Mirca, Dusi, Sabrina, Tosi, Elena, Tiranti, Valeria, Goffrini, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Shared Science Publishers OG 2015
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348974/
https://ncbi.nlm.nih.gov/pubmed/28357284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2015.04.196
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