Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism

Mutations in nuclear genes associated with defective coenzyme A biosynthesis have been identified as responsible for some forms of neurodegeneration with brain iron accumulation (NBIA), namely PKAN and CoPAN. PKAN are defined by mutations in PANK2, encoding the pantothenate kinase 2 enzyme, that acc...

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Bibliografski detalji
Izdano u:Microb Cell
Glavni autori: Ceccatelli Berti, Camilla, Dallabona, Cristina, Lazzaretti, Mirca, Dusi, Sabrina, Tosi, Elena, Tiranti, Valeria, Goffrini, Paola
Format: Artigo
Jezik:Inglês
Izdano: Shared Science Publishers OG 2015
Teme:
Microbiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348974/
https://ncbi.nlm.nih.gov/pubmed/28357284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2015.04.196
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