Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism

Mutations in nuclear genes associated with defective coenzyme A biosynthesis have been identified as responsible for some forms of neurodegeneration with brain iron accumulation (NBIA), namely PKAN and CoPAN. PKAN are defined by mutations in PANK2, encoding the pantothenate kinase 2 enzyme, that acc...

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Detaylı Bibliyografya
Yayımlandı:Microb Cell
Asıl Yazarlar: Ceccatelli Berti, Camilla, Dallabona, Cristina, Lazzaretti, Mirca, Dusi, Sabrina, Tosi, Elena, Tiranti, Valeria, Goffrini, Paola
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Shared Science Publishers OG 2015
Konular:
Microbiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348974/
https://ncbi.nlm.nih.gov/pubmed/28357284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2015.04.196
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