Protein misfolding in neurodegenerative diseases: implications and strategies

A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently being explored that target different steps in the production and processing of proteins im...

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Veröffentlicht in:Transl Neurodegener
Hauptverfasser: Sweeney, Patrick, Park, Hyunsun, Baumann, Marc, Dunlop, John, Frydman, Judith, Kopito, Ron, McCampbell, Alexander, Leblanc, Gabrielle, Venkateswaran, Anjli, Nurmi, Antti, Hodgson, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348787/
https://ncbi.nlm.nih.gov/pubmed/28293421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-017-0077-5
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