Gankyrin sustains PI3K/GSK-3β/β-catenin signal activation and promotes colorectal cancer aggressiveness and progression

High levels of angiogenesis, metastasis and chemoresistance are major clinical features of colorectal cancer (CRC), a lethal disease with a high incidence worldwide. Aberrant activation of Wnt/β-catenin pathway contributes to CRC progression. However, little is known about regulatory mechanisms of t...

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Udgivet i:Oncotarget
Main Authors: He, Feng, Chen, Huacui, Yang, Ping, Wu, Qianlong, Zhang, Tong, Wang, Chengxing, Wei, Jianchang, Chen, Zhuanpeng, Hu, He, Li, Wanglin, Cao, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348383/
https://ncbi.nlm.nih.gov/pubmed/27835604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13215
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