MEK1 is required for the development of NRAS-driven leukemia

The dual-specificity kinases MEK1 and MEK2 act downstream of RAS/RAF to induce ERK activation, which is generally considered protumorigenic. Activating MEK mutations have not been discovered in leukemia, in which pathway activation is caused by mutations in upstream components such as RAS or Flt3. T...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Nowacka, Joanna D., Baumgartner, Christian, Pelorosso, Cristiana, Roth, Mareike, Zuber, Johannes, Baccarini, Manuela
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Priority Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348309/
https://ncbi.nlm.nih.gov/pubmed/27741509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12555
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