Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation

Altered expression of NEAT1, the architectural long non-coding RNA (lncRNA) of nuclear paraspeckles, has been reported during tumorigenesis, as well as under various cellular stress conditions. Here we report that the depletion of NEAT1 lncRNA alleviates nucleolar stress during RNAP I inhibition thr...

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Veröffentlicht in:PLoS One
Hauptverfasser: Shen, Wen, Liang, Xue-hai, Sun, Hong, De Hoyos, Cheryl L., Crooke, Stanley T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348036/
https://ncbi.nlm.nih.gov/pubmed/28288210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173494
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