Maternal use of drug substrates of placental transporters and the effect of transporter-mediated drug interactions on the risk of congenital anomalies

BACKGROUND: A number of transporter proteins are expressed in the placenta, and they facilitate the placental transfer of drugs. The inhibition of P-glycoprotein (P-gp) was previously found to be associated with an increase in the risk of congenital anomalies caused by drug substrates of this transp...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Daud, Aizati N. A., Bergman, Jorieke E. H., Oktora, Monika P., Kerstjens-Frederikse, Wilhelmina S., Groen, Henk, Bos, Jens H., Hak, Eelko, Wilffert, Bob
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348032/
https://ncbi.nlm.nih.gov/pubmed/28288183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173530
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