P-Glycoprotein-Mediated Drug Interactions in Pregnancy and Changes in the Risk of Congenital Anomalies: A Case-Reference Study

INTRODUCTION: Drug use in pregnancy is very common but may cause harm to the fetus. The teratogenic effect of a drug is partly dependent on the drug level in the fetal circulation, which is associated with the transport across the placenta. Many drugs are substrates of P-glycoprotein (P-gp), an effl...

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Detalhes bibliográficos
Publicado no:Drug Saf
Main Authors: Daud, Aizati N. A., Bergman, Jorieke E. H., Bakker, Marian K., Wang, Hao, Kerstjens-Frederikse, Wilhelmina S., de Walle, Hermien E. K., Groen, Henk, Bos, Jens H. J., Hak, Eelko, Wilffert, Bob
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486783/
https://ncbi.nlm.nih.gov/pubmed/26017034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40264-015-0299-3
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