Antitumor efficacy of radiation plus immunotherapy depends upon dendritic cell activation of effector CDS(+) T cells

Tumor cells dying after cytotoxic therapy are a potential source of antigen for T-cell priming. Antigen-presenting cells (APCs) can cross-present MHC I–restricted peptides after the uptake of dying cells. Depending on the nature of the surrounding environmental signals, APCs then orchestrate a spect...

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Veröffentlicht in:Cancer Immunol Res
Hauptverfasser: Dovedi, Simon J., Lipowska-Bhalla, Grazyna, Beers, Stephen A., Cheadle, Eleanor J., Mu, Lijun, Glennie, Martin J., Illidge, Timothy M., Honeychurch, Jamie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348028/
https://ncbi.nlm.nih.gov/pubmed/27241845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0253
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