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Rapid Activation of Transforming Growth Factor β–Activated Kinase 1 in Chondrocytes by Phosphorylation and K(63)‐Linked Polyubiquitination Upon Injury to Animal Articular Cartilage
OBJECTIVE: Mechanical injury to cartilage predisposes to osteoarthritis (OA). Wounding of the articular cartilage surface causes rapid activation of MAP kinases and NF‐κB, mimicking the response to inflammatory cytokines. This study was undertaken to identify the upstream signaling mechanisms involv...
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| 出版年: | Arthritis Rheumatol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5347887/ https://ncbi.nlm.nih.gov/pubmed/27768832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39965 |
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