Rapid Activation of Transforming Growth Factor β–Activated Kinase 1 in Chondrocytes by Phosphorylation and K(63)‐Linked Polyubiquitination Upon Injury to Animal Articular Cartilage

OBJECTIVE: Mechanical injury to cartilage predisposes to osteoarthritis (OA). Wounding of the articular cartilage surface causes rapid activation of MAP kinases and NF‐κB, mimicking the response to inflammatory cytokines. This study was undertaken to identify the upstream signaling mechanisms involv...

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Bibliographic Details
Published in:Arthritis Rheumatol
Main Authors: Ismail, Heba M., Didangelos, Athanasios, Vincent, Tonia L., Saklatvala, Jeremy
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Osteoarthritis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347887/
https://ncbi.nlm.nih.gov/pubmed/27768832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39965
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