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Rapid Activation of Transforming Growth Factor β–Activated Kinase 1 in Chondrocytes by Phosphorylation and K(63)‐Linked Polyubiquitination Upon Injury to Animal Articular Cartilage
OBJECTIVE: Mechanical injury to cartilage predisposes to osteoarthritis (OA). Wounding of the articular cartilage surface causes rapid activation of MAP kinases and NF‐κB, mimicking the response to inflammatory cytokines. This study was undertaken to identify the upstream signaling mechanisms involv...
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| Udgivet i: | Arthritis Rheumatol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5347887/ https://ncbi.nlm.nih.gov/pubmed/27768832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39965 |
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