Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma

Neuroblastoma (NB), which accounts for about 15% of cancer-related mortality in children, is the most common childhood extracranial malignant tumor. In NB, somatic mutations of the tumor suppressor, p53, are exceedingly rare. Unlike in adult tumors, the majority of p53 downstream functions are still...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lu, Jiaxiong, Guan, Shan, Zhao, Yanling, Yu, Yang, Wang, Yongfeng, Shi, Yonghua, Mao, Xinfang, Yang, Kristine L., Sun, Wenjing, Xu, Xin, Yi, Joanna S., Yang, Tianshu, Yang, Jianhua, Nuchtern, Jed G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347730/
https://ncbi.nlm.nih.gov/pubmed/27764791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12634
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