Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models

Mutations in the glucocerebrosidase gene (GBA) confer a heightened risk of developing Parkinson’s disease (PD) and other synucleinopathies, resulting in a lower age of onset and exacerbating disease progression. However, the precise mechanisms by which mutations in GBA increase PD risk and accelerat...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sardi, S. Pablo, Viel, Catherine, Clarke, Jennifer, Treleaven, Christopher M., Richards, Amy M., Park, Hyejung, Olszewski, Maureen A., Dodge, James C., Marshall, John, Makino, Elina, Wang, Bing, Sidman, Richard L., Cheng, Seng H., Shihabuddin, Lamya S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347608/
https://ncbi.nlm.nih.gov/pubmed/28223512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616152114
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