Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

Voltage-gated sodium channels (Navs) play crucial roles in excitable cells. Although vertebrate Nav function has been extensively studied, the detailed structural basis for voltage-dependent gating mechanisms remain obscure. We have assessed the structural changes of the Nav voltage sensor domain us...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kubota, Tomoya, Durek, Thomas, Dang, Bobo, Finol-Urdaneta, Rocio K., Craik, David J., Kent, Stephen B. H., French, Robert J., Bezanilla, Francisco, Correa, Ana M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347571/
https://ncbi.nlm.nih.gov/pubmed/28202723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700453114
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