Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity

[Image: see text] Histone deacetylase (HDAC) proteins are epigenetic regulators that deacetylate protein substrates, leading to subsequent changes in cell function. HDAC proteins are implicated in cancers, and several HDAC inhibitors have been approved by the FDA as anticancer drugs, including SAHA...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Negmeldin, Ahmed T., Padige, Geetha, Bieliauskas, Anton V., Pflum, Mary Kay H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2017
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346987/
https://ncbi.nlm.nih.gov/pubmed/28337317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00124
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