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Development of [(18)F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging

[Image: see text] Dysregulation of glycogen synthase kinase-3β (GSK-3β) is implicated in the pathogenesis of neurodegenerative and psychiatric disorders. Thus, development of GSK-3β radiotracers for positron emission tomography (PET) imaging is of paramount importance, because such a noninvasive ima...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Hu, Kongzhen, Patnaik, Debasis, Collier, Thomas Lee, Lee, Katarzyna N., Gao, Han, Swoyer, Matthew R., Rotstein, Benjamin H., Krishnan, Hema S., Liang, Steven H., Wang, Jin, Yan, Zhiqiang, Hooker, Jacob M., Vasdev, Neil, Haggarty, Stephen J., Ngai, Ming-Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346984/
https://ncbi.nlm.nih.gov/pubmed/28337318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00405
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