In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC

Clinical PI3K inhibition has been somewhat disappointing, due to both inadequate patient stratification and compensatory cell signalling through bypass mechanisms. As such, investigation of PI3K-MEK co-targeted inhibition has been recommended. With high mortality rates and a clear need for new thera...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Heavey, Susan, Cuffe, Sinead, Finn, Stephen, Young, Vincent, Ryan, Ronan, Nicholson, Siobhan, Leonard, Niamh, McVeigh, Niall, Barr, Martin, O'Byrne, Kenneth, Gately, Kathy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346733/
https://ncbi.nlm.nih.gov/pubmed/27765909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12755
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