KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models

BACKGROUND: In non-small cell lung cancer (NSCLC) KRAS-mutant status is a negative prognostic and predictive factor. Nitrogen-containing bisphosphonates inhibit prenylation of small G-proteins (e.g. Ras, Rac, Rho) and thus may affect proliferation and migration. In our preclinical work, we investiga...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kenessey, István, Kói, Krisztina, Horváth, Orsolya, Cserepes, Mihály, Molnár, Dávid, Izsák, Vera, Dobos, Judit, Hegedűs, Balázs, Tóvári, József, Tímár, József
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346731/
https://ncbi.nlm.nih.gov/pubmed/27780929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12806
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