Utilization of leukapheresis and CD4 positive selection in Treg isolation and the ex-vivo expansion for a clinical application in transplantation and autoimmune disorders

Adoptive transfer of T regulatory cells (Tregs) is of great interest as a novel immunosuppressive therapy in autoimmune disorders and transplantation. Obtaining a sufficient number of stable and functional Tregs generated according to current Good Manufacturing Practice (cGMP) requirements has been...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Gołąb, Karolina, Grose, Randall, Trzonkowski, Piotr, Wickrema, Amittha, Tibudan, Martin, Marek-Trzonkowska, Natalia, Matosz, Sabrina, Solomina, Julia, Ostrega, Diane, Millis, J. Michael, Witkowski, Piotr
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346728/
https://ncbi.nlm.nih.gov/pubmed/27821811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13101
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