Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain

Autophagy is a highly conserved mechanism that degrades long-lived proteins and dysfunctional organelles, and contributes to cell fate. In this study, autophagy attenuates Notch1 signaling by degrading the Notch1 intracellular domain (Notch1-IC). Nutrient-deprivation promotes Notch1-IC phosphorylati...

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Udgivet i:Oncotarget
Main Authors: Ahn, Ji-Seon, Ann, Eun-Jung, Kim, Mi-Yeon, Yoon, Ji-Hye, Lee, Hye-Jin, Jo, Eun-Hye, Lee, Keesook, Lee, Ji Shin, Park, Hee-Sae
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
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Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346697/
https://ncbi.nlm.nih.gov/pubmed/27806347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12986
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