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Ablation of the cardiac ryanodine receptor phospho-site Ser2808 does not alter the adrenergic response or the progression to heart failure in mice: Elimination of the genetic background as critical variable

BACKGROUND: Phosphorylation of the cardiac ryanodine receptor (RyR2) phospho-site S2808 has been touted by the Marks group as a hallmark of heart failure (HF) and a critical mediator of the physiological fight-or-flight response of the heart. In support of this hypothesis, mice unable to undergo pho...

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Vydáno v:J Mol Cell Cardiol
Hlavní autoři: Alvarado, Francisco J., Chen, Xi, Valdivia, Héctor H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346485/
https://ncbi.nlm.nih.gov/pubmed/28065668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.01.001
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